First Aid Measures Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment Solubility lab benzophenone are inadequate.
Limit dosages and durations to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation.
Xanax Description Xanax Tablets contain alprazolam which is a triazolo analog of the 1,4 benzodiazepine class of central nervous system-active compounds. The structural formula is represented to the right: Alprazolam is a white crystalline powder, which is soluble in methanol or ethanol but which has no appreciable solubility in water at physiological pH.
Each Xanax Tablet, for oral administration, contains 0. Xanax Tablets, 2 mg, are multi-scored and may be divided as shown below: Cellulose, corn starch, docusate sodium, lactose, magnesium stearate, silicon dioxide and sodium benzoate.
In addition, the 0.
Xanax - Clinical Pharmacology Pharmacodynamics CNS agents of the 1,4 benzodiazepine class presumably exert their effects by binding at stereo specific receptors at several sites within the central nervous system. Their exact mechanism of action is unknown. Clinically, all benzodiazepines cause a dose-related central nervous system depressant activity varying from mild impairment of task performance to hypnosis.
Pharmacokinetics Absorption Following oral administration, alprazolam is readily absorbed. Peak concentrations in the plasma occur in 1 to 2 hours following administration.
Plasma levels are proportionate to the dose given; over the dose range of 0.
Using a specific assay methodology, the mean plasma elimination half-life of alprazolam has been found to be about Distribution In vitro, alprazolam is bound 80 percent to human serum protein.
Serum albumin accounts for the majority of the binding. A benzophenone derived from alprazolam is also found in humans. Their half-lives appear to be similar to that of alprazolam.
The reported relative potencies in benzodiazepine receptor binding experiments and in animal models of induced seizure inhibition are 0. The benzophenone metabolite is essentially inactive.
Alprazolam and its metabolites are excreted primarily in the urine. Special Populations Changes in the absorption, distribution, metabolism and excretion of benzodiazepines have been reported in a variety of disease states including alcoholism, impaired hepatic function and impaired renal function.
Changes have also been demonstrated in geriatric patients.
A mean half-life of alprazolam of In patients with alcoholic liver disease the half-life of alprazolam ranged between 5. In an obese group of subjects the half-life of alprazolam ranged between 9.
Because of its similarity to other benzodiazepines, it is assumed that alprazolam undergoes transplacental passage and that it is excreted in human milk. Pediatrics The pharmacokinetics of alprazolam in pediatric patients have not been studied.
Gender Gender has no effect on the pharmacokinetics of alprazolam.
Most of the interactions that have been documented with alprazolam are with drugs that inhibit or induce CYP3A4. Compounds that are potent inhibitors of CYP3A would be expected to increase plasma alprazolam concentrations.
Drug products that have been studied in vivo, along with their effect on increasing alprazolam AUC, are as follows: CYP3A inducers would be expected to decrease alprazolam concentrations and this has been observed in vivo.
The oral clearance of alprazolam given in a 0.A hydroxybenzophenone that is benzophenone which is substituted at the 2- and 4-positions of one of the benzene rings by hydroxy and methoxy groups respectively. ACS AuthorChoice - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
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At higher concentrations, benzophenone is a contact irritant affecting eyes, skin, and respiratory system. Benzophenone is moderately toxic by ingestion. Workplace exposure 5,6. A hydroxybenzophenone that is benzophenone which is substituted at the 2- and 4-positions of one of the benzene rings by hydroxy and methoxy groups respectively. Here’s the biggest difference between what you experienced in your college organic chemistry lab versus a cosmetic formulation lab. In an organic lab, you mix chemicals together and hope something happens.
IntroductionThese days a large number of synthetic polymeric materials with various different properties are available for medical applications like prostheses, . Open Access Initiative is committed to make genuine and reliable contributions to the scientific community without restricting the access of published content.
Benzophenone is polar, where as, hexane is nonpolar. "water-loving"). As the hydrocarbon chain becomes longer, the hydrophobic character of the molecule increases, and the solubility of the alcohol in water gradually decreases until it becomes essentially insoluble in water.
Effect of Temperature on the Solubility Of a Salt in Water Lab.